Deconstructing negative symptoms in schizophrenia
Even when medication succeeds in tempering their psychosis, most people with schizophrenia struggle to create full, meaningful lives with independentContinue Reading
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WCPG 2012 — Baby steps for sequencing in schizophrenia
More than 600 people gathered in Hamburg, Germany, 14-18 October, to attend the 20th World Congress of Psychiatric Genetics. NewContinue Reading
Exome sequencing hints at prenatal genes in schizophrenia
Another round of sequencing in schizophrenia offers up a new batch of genetic mutations in sporadic cases of the disorder.Continue Reading
Simulating schizophrenia with ketamine
Disrupting glutamate signals in the brain blurs the contrast between the brain’s background “default” activity and its task-related engagement, accordingContinue Reading
Deficient interneurons in schizophrenia
In schizophrenia, the cortex is short of transcripts for a protein critical for interneuron development, according to a postmortem studyContinue Reading
What’s the matter with white matter in schizophrenia?
Three studies published in the Archives of General Psychiatry in September identify schizophrenia-related changes in white matter, the bundles ofContinue Reading
New mutations mount as fathers age
As a man ages, the chance that his children will carry new, spontaneously occurring mutations grows, according to a studyContinue Reading
Teenage training
Training in adolescence can offset cognitive deficits in adulthood in a proposed rat model of schizophrenia, reports a study inContinue Reading
Antipsychotics enhance reward signals, with mixed results
Antipsychotics elevate signals in the brain’s reward pathways, with wanted and unwanted effects, according to two new brain imaging studiesContinue Reading
Through neurexin the twain shall meet
Two studies describe how neurexin, a molecule implicated in schizophrenia, helps assemble and maintain the disparate sides of the synapse.Continue Reading
No medium rare for schizophrenia genetics?
The rare genetic glitches with large contributions to schizophrenia risk may be scarce indeed, according to a new sequencing studyContinue Reading
Picking PIK3CD for schizophrenia treatment
A new study plunges into the detailed workings of cells from people with schizophrenia, and emerges with an enzyme calledContinue Reading
Michele Solis 