Schizophrenia Research Forum

Simulating schizophrenia with ketamine

Disrupting glutamate signals in the brain blurs the contrast between the brain’s background “default” activity and its task-related engagement, according to a study published online 25 September in Proceedings of the National Academy of Sciences. The findings suggest that glutamate regulates the flow of information within the brain’s networks, which, when disrupted with ketamine, reveals schizophrenia-like abnormalities in healthy people.

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