Schizophrenia Research Forum meeting reports

This year I’ve traveled near and far to cover the latest schizophrenia-related findings at three different meetings. This turned into nine meeting reports published at Schizophrenia Research Forum.


2013 World Congress of Psychiatric Genetics Boston, MA

Substantial Genetic Leads Emerge for Schizophrenia 10/23/13
New Mutations Pop Up in Schizophrenia Genomes 10/31/13
Genetic Links Across Disorders 11/6/13


OHBM 2013 logo2013 Organization for Human Brain Mapping
Seattle, WA

Human Brain Imagers Convene in Seattle 7/12/13


Orlando2013 International Congress on Schizophrenia Research
Orlando, FL


Identifying and Treating the Psychosis Prodrome 4/26/13
Divvying Up the Prodrome 4/30/13
Mysterious RNAs Provide Clues for Schizophrenia 5/13/2013
Olfactory Clues to Schizophrenia 5/24/13
The Research Enterprise, as Seen by People With Schizophrenia 6/25/13

Schizophrenia Research Forum Omnibus

Here I post a backlog of news stories I’ve written for Schizophrenia Research Forum since March 2013 — 30 in all!


For me, highlights include two landmark studies finding common genetic roots among different psychiatric disorders (Landmark GWAS Links Different Disorders To Same SNPs 3/7/13, and Substantial Genetic Overlaps Measured Between Psychiatric Disorders 8/20/13), the CLARITY technique that reveals intricate details of brain structure (Brain Anatomy Revealed With CLARITY 3/10/13), and an interesting idea about how delusions remain so fixed in schizophrenia (Delusions Linked to Bottom-Up and Top-Down Processes 9/23/13).


The remaining stories are listed here:
Dopamine Signals Stall Dendritic Spine Formation in Young Mice 10/15/13
Data Support Kraepelinian Boundary Between Psychotic Disorders 10/9/13
Monkey Model of Schizophrenia Debuts 9/26/13
Altered Connections Between Cortex and Striatum Mark Psychosis Risk 9/17/13
Summer of Salience: Insula Fingered in Schizophrenia 9/10/13
Ambitious Genetic Integration Analysis of Schizophrenia Points to Early Brain Development 8/2/13
Can Experimentally “Created” Memories Help Explain Delusions? 7/31/13
DISC1 Tied to Motivation, Oxidative Stress in Mice 7/16/13
Neurexin Splicing Exerts Control Across the Synapse 7/11/13
Methamphetamine Points to Reward-Learning Deficits Underlying Psychosis 7/10/13
Schizophrenia and Bipolar With Psychosis Share Cognition, Connectivity 7/5/13
ADHD and Schizophrenia Share Some Genetic Risk 6/28/13
Can a Simple Amino Acid Treat Schizophrenia? 6/25/13
Brain Anomalies in Schizophrenia Arise Early, Degrade Connectivity 6/18/13
Surprise Signals: Optogenetics Links Dopamine to Prediction Errors 6/10/13
Schizophrenia-like Nrg1 Overabundance Repaired in Adult Mice 6/3/13
Perineuronal Nets Protect Interneurons Linked to Schizophrenia 5/17/13
Sodium Nitroprusside Rapidly Quells Schizophrenia Symptoms 5/10/13
Family Study Replicates Genetic Signals for Schizophrenia 4/19/13
ENCODE Explained to the Rest of Us 4/11/13
Dissecting Phenotype to Approach Genetics of Schizophrenia 4/4/13
Dialing Down Thalamus Disrupts Synchrony, Cognition 3/29/13
The Structure of Bias at Serotonin Receptors 3/26/13
Divide and Conquer: Isolating Negative Symptoms in Schizophrenia 3/20/13
MIR137 Associated With Age of Onset, Brain Structure in Schizophrenia 3/18/13
Genetics Roundup: Motley Crew of Variants Kicks Off 2013 3/12/13

Simulating schizophrenia with ketamine

Disrupting glutamate signals in the brain blurs the contrast between the brain’s background “default” activity and its task-related engagement, according to a study published online 25 September in Proceedings of the National Academy of Sciences. The findings suggest that glutamate regulates the flow of information within the brain’s networks, which, when disrupted with ketamine, reveals schizophrenia-like abnormalities in healthy people.

Read this story at Schizophrenia Research Forum.

Personality circuits

We typically reveal our personalities through our behavior, but a new study suggests it might be apparent even when we are at rest — at least inside a brain scanner. In a study in PLoS One, researchers report that personality traits correlate with brain activity when a person is awake but not engaged in a task.

Read this article at Scientific American Mind.