Target potassium channels for schizophrenia?
Adding extra dopamine receptors to the mouse striatum—a manipulation that models the overactive dopamine signaling hypothesized in schizophrenia—can substantially remodelContinue Reading
Tag: schizophrenia
DNA damage
Disorder-specific patterns of DNA damage in neurons mark the brain in schizophrenia and bipolar disorder, according to a recent studyContinue Reading
Collective commons
Common variants capture at least 23 percent of liability for schizophrenia, according to a study published in Nature Genetics. TheContinue Reading
Intracellular gridlock
Proteins encoded by DISC1, a gene suspected in schizophrenia, can clump together and slow transport of essential components inside aContinue Reading
Teenage brain drain
Teenagers struck by early-onset psychosis quickly exhibit brain volume decreases over two years, according to a new study in theContinue Reading
Omens of psychosis?
An overactive dopamine system in the brain precedes the onset of psychosis, according to a recent study in American JournalContinue Reading
Spontaneous mutations linked to bipolar disorder
Bipolar disorder has joined the ranks of brain disorders associated with mutations called copy number variations (CNVs) — specifically spontaneously-occurringContinue Reading
Uninherited genetic glitches in schizophrenia
People with schizophrenia carry a higher number of copy number variations (CNVs) — gains and losses of DNA segments —Continue Reading
DISC1: Of mice, men, and…amoebas?
Recent findings in humans, mice, zebrafish, and even the humble amoeba offer new insights, confirm older ones, and in someContinue Reading
Antipsychotic balancing act?
A new study in Cell proposes that the therapeutic effects of both atypical antipsychotic drugs and the newer glutamate candidates dependContinue Reading
