DSM-5 field tests reliably detect schizophrenia

Clinicians trying out the new version of the Diagnostic and Statistical Manual of Mental Disorders, the DSM-5, largely come to the same conclusions, according to a trio of papers published online October 30 in the American Journal of Psychiatry. For schizophrenia, reliability in diagnosis and in dimensional measures of psychosis scored in the “good” range.

Read this story at Schizophrenia Research Forum.

DNA damage

Disorder-specific patterns of DNA damage in neurons mark the brain in schizophrenia and bipolar disorder, according to a recent study in Archives of General Psychiatry. This suggests that the cellular controls that keep the genome in good working order inside each neuron are disrupted in these mental illnesses.

Read this article at Schizophrenia Research Forum.

Spontaneous mutations linked to bipolar disorder

Bipolar disorder has joined the ranks of brain disorders associated with mutations called copy number variations (CNVs) — specifically spontaneously-occurring ones — in a new study published in Neuron. The findings suggest that bipolar disorder lies on the milder end of a continuum of brain disorders that includes schizophrenia, autism, and intellectual disability.

Read this article at Schizophrenia Research Forum.