Widespread gene disruption in brain in schizophrenia

Subtle yet widespread disruptions in gene expression mark the brain in schizophrenia, according to a study of over 500 brain samples  published in Nature Neuroscience on September 26. From the CommonMind Consortium, the study sequenced RNA messages to provide the most comprehensive picture yet of gene expression in the brain in schizophrenia.

The effort linked 20 percent of genetic risk signals previously identified for schizophrenia to changes in gene expression, pegged multiple suspect genes with roles in brain development, and detected 693 genes that were expressed slightly differently in schizophrenia, ranging from 1.03- to 1.33-fold changes compared to controls.

Read this story at Schizophrenia Research Forum.

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