The long arm of dopamine signaling

Altering dopamine signaling in one part of the brain can have substantial repercussions elsewhere, according to a new study in Proceedings of the National Academy of Sciences. Adding extra D2 dopamine receptors to the striatum of mice decreased inhibitory signals in the cortex — a result that suggests that the debilitating cognitive impairments of schizophrenia originate from defects in the striatum, rather than cortex.

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