Altering dopamine signaling in one part of the brain can have substantial repercussions elsewhere, according to a new study in Proceedings of the National Academy of Sciences. Adding extra D2 dopamine receptors to the striatum of mice decreased inhibitory signals in the cortex — a result that suggests that the debilitating cognitive impairments of schizophrenia originate from defects in the striatum, rather than cortex.
Michele Solis 
Altering dopamine signaling in one part of the brain can have substantial repercussions elsewhere, according to a new study in Proceedings of the National Academy of Sciences. Adding extra D2 dopamine receptors to the striatum of mice decreased inhibitory signals in the cortex — a result that suggests that the debilitating cognitive impairments of schizophrenia originate from defects in the striatum, rather than cortex.