SIRS 2012 — The pile of schizophrenia genetics puzzle pieces grows

More than 1,600 researchers and clinicians gathered in a Florence from 14-18 April 2012 to discuss new schizophrenia research at the Third Schizophrenia International Research Society (SIRS) conference. There, researchers highlighted their latest genetics findings, which illustrated that raw information — even the high-resolution kind provided by sequencing — is no substitute for a true understanding of the genetic roots of the disorder.

Read this meeting report at Schizophrenia Research Forum.

Autism exomes revealed

Spontaneously occurring, protein-altering mutations likely contribute to some cases of autism, according to a trio of the largest-to-date exome sequencing studies of the disorder published in Nature. The papers forge a path for others to follow in the tricky business of linking mutations — even rare, nasty ones — to disease.

Read this article in Schizophrenia Research Forum.

World Congress of Psychiatric Genetics 2010

New genetic clues for schizophrenia were unveiled at WCPG 2010 in Athens, Greece, where researchers emphasized that the hunt for genes underlying psychiatric disorders has only just begun. Three reports cover the highlights for Schizophrenia Research Forum.

Copy number variants in schizophrenia update: The outright deletions or duplications of segments of DNA, called copy number variants, increase risk for schizophrenia.

The sequencing floodgates open with a trickle: For those who thought that capturing the full extent of genetic variation through sequencing would get at the heart of genetic risk for schizophrenia, a series of talks with preliminary data was a sobering experience.

Bigger GWAS approach gets much support: Many researchers argued that large genome-wide association studies (GWAS) of schizophrenia and other disorders are just starting to deliver.