Dynamic duo
The protein encoded by DISC1, the disrupted in schizophrenia 1 gene, partners with the protein Dixdc1 in mice to regulateContinue Reading
Tag: schizophrenia
Synaptic convergence
A new study fingers a diverse array of copy number variants (CNVs) — duplications or deletions of DNA — in schizophrenia. ManyContinue Reading
Neurexin goes it alone
Known for partnering with other proteins to shape the connections between neurons called synapses, neurexins may powerfully regulate these junctionsContinue Reading
A mixed economy of schizophrenia genetics
A new mutation in the SHANK3 gene adds to the burgeoning catalog of genetic variants — both rare and common — foundContinue Reading
Interneurons set stage for key schizophrenia molecules
Two new studies show that the neurons in charge of dampening electrical activity in the brain — known as interneuronsContinue Reading
Disorganized brain signals in a mouse model of schizophrenia
Mice carrying a multi-gene deletion associated with schizophrenia exhibit disrupted communication between regions of the brain involved in working memory.Continue Reading
What lies between: extracellular matrix and schizophrenia
When searching for clues to schizophrenia in the brain, it’s important to look in the seemingly open space between neuronsContinue Reading
Serotonin receptors reduced in first-episode schizophrenia
The frontal cortex in people with schizophrenia contains abnormally low levels of the 5HT2A type of serotonin receptor, according to aContinue Reading
LRRTM2: A new synaptic partner for neurexin
A synapse-promoting protein called LRRTM2 has been identified as a ligand for neurexin, a protein linked to schizophrenia, autism andContinue Reading
Meet Norbin
Researchers have identified the protein Norbin as a behind the scenes booster of metabotropic glutamate receptors. This suggests a potentialContinue Reading
Getting specific with a mouse model of schizophrenia
Removing a subset of NMDA receptors in mice early in development can disrupt neural circuits and behavior in ways thatContinue Reading
GABA unleashed (from the synapse)
In the grand spectacle of neuronal communication, there is a new player on the scene: neurogliaform cells. A new paperContinue Reading
Michele Solis 