DNA damage

Disorder-specific patterns of DNA damage in neurons mark the brain in schizophrenia and bipolar disorder, according to a recent study in Archives of General Psychiatry. This suggests that the cellular controls that keep the genome in good working order inside each neuron are disrupted in these mental illnesses.

Read this article at Schizophrenia Research Forum.

Spontaneous mutations linked to bipolar disorder

Bipolar disorder has joined the ranks of brain disorders associated with mutations called copy number variations (CNVs) — specifically spontaneously-occurring ones — in a new study published in Neuron. The findings suggest that bipolar disorder lies on the milder end of a continuum of brain disorders that includes schizophrenia, autism, and intellectual disability.

Read this article at Schizophrenia Research Forum.