DNA damage

Disorder-specific patterns of DNA damage in neurons mark the brain in schizophrenia and bipolar disorder, according to a recent study in Archives of General Psychiatry. This suggests that the cellular controls that keep the genome in good working order inside each neuron are disrupted in these mental illnesses.

Read this article at Schizophrenia Research Forum.

Spontaneous mutations linked to bipolar disorder

Bipolar disorder has joined the ranks of brain disorders associated with mutations called copy number variations (CNVs) — specifically spontaneously-occurring ones — in a new study published in Neuron. The findings suggest that bipolar disorder lies on the milder end of a continuum of brain disorders that includes schizophrenia, autism, and intellectual disability.

Read this article at Schizophrenia Research Forum.

World Congress of Psychiatric Genetics 2010

New genetic clues for schizophrenia were unveiled at WCPG 2010 in Athens, Greece, where researchers emphasized that the hunt for genes underlying psychiatric disorders has only just begun. Three reports cover the highlights for Schizophrenia Research Forum.

Copy number variants in schizophrenia update: The outright deletions or duplications of segments of DNA, called copy number variants, increase risk for schizophrenia.

The sequencing floodgates open with a trickle: For those who thought that capturing the full extent of genetic variation through sequencing would get at the heart of genetic risk for schizophrenia, a series of talks with preliminary data was a sobering experience.

Bigger GWAS approach gets much support: Many researchers argued that large genome-wide association studies (GWAS) of schizophrenia and other disorders are just starting to deliver.